Centennial Baseball
| Date | Opponent | Results |
| Mon 5/24/21 | at Ottumwa | L 1-2, L 0-1 |
| Wed 5/26/21 | at Johnston | L 0-10 (6 inn.) |
| Tue 6/1/21 | Fort Dodge (DH) | W 4-3, L 3-5 |
| Wed 6/2/21 | Des Moines Roosevelt (DH) | W 12-2 (6 inn.), W 7-3 |
| Fri 6/4/21 | Urbandale | L 5-12 |
| Sat 6/5/21 | North Polk | W 12-2 (5 inn.) |
| Davenport North | L 3-4 | |
| Mon 6/7/21 | at Marshalltown (DH) | W 12-8, L 8-10 |
| Wed 6/9/21 | Ankeny (DH) | L 2-4, L 0-7 |
| Thu 6/10/21 | at Knoxville | W 11-3 |
| Sat 6/12/21 | at Mount Mercy, vs. Muscatine | W 12-5 |
| vs. Cedar Rapids Kennedy | L 5-6 | |
| Mon 6/14/21 | at Ames (DH) | |
| Wed 6/16/21 | Mason City (DH) | |
| Thu 6/17/21 | Des Moines North (DH) | |
| Mon 6/21/21 | at Fort Dodge (DH) | |
| Wed 6/23/21 | Marshalltown (DH) | |
| Sat 6/26/21 | Prange Classic at Saydel, vs. Pleasant Valley | |
| vs. Gilbert | ||
| Mon 6/28/21 | at Ankeny (DH) | |
| Wed 6/30/21 | Ames (DH) | |
| Mon 7/5/21 | at Mason City (DH) | |
| Wed 7/7/21 | Waukee (DH) | |
| Sat 7/10/21 | at Sioux City North (DH) | |
| Mon 7/12/21 | at Dowling Catholic (DH) | |
| Fri 7/16/21 | at TBA, Class 4A Substate Quarterfinal |