Ankeny Football
| Date | Opponent | Results |
| Fri 8/27/21 | Waukee | |
| Fri 9/3/21 | at Ankeny Centennial | |
| Fri 9/10/21 | at Valley Stadium, vs. Dowling Catholic | |
| Fri 9/17/21 | Southeast Polk (Homecoming) | |
| Fri 9/24/21 | Des Moines Roosevelt | |
| Fri 10/1/21 | at Valley | |
| Fri 10/8/21 | Des Moines North | |
| Fri 10/15/21 | at Waukee Northwest | |
| Fri 10/22/21 | Des Moines Lincoln (Senior Night) | |
| Fri 10/29/21 | Class 4A Playoffs, First Round | |
| Fri 11/5/21 | Class 4A Quarterfinals, TBA | |
| Fri 11/12/21 | Class 4A Semifinals at UNI-Dome | |
| Fri 11/19/21 | Class 4A Championship at UNI-Dome |