Ankeny Football
| Date | Opponent | Results |
| Fri 8/27/21 | Waukee | W 49-0 |
| Fri 9/3/21 | at Ankeny Centennial | L 7-14 |
| Fri 9/10/21 | at Valley Stadium, vs. Dowling Catholic | W 27-13 |
| Fri 9/17/21 | Southeast Polk (Homecoming) | W 21-7 |
| Fri 9/24/21 | Des Moines Roosevelt | W 49-6 |
| Fri 10/1/21 | at Valley | L 35-38 |
| Fri 10/8/21 | Des Moines North | W 56-7 |
| Fri 10/15/21 | at Waukee Northwest | W 48-7 |
| Fri 10/22/21 | Des Moines Lincoln (Senior Night) | W 56-0 |
| Fri 10/29/21 | Class 5A First Round, vs. Waukee Northwest | W 42-3 |
| Fri 11/5/21 | Class 5A Quarterfinals, at C.R. Prairie | W 37-7 |
| Fri 11/12/21 | Class 5A Semifinals at UNI-Dome, vs. Valley | W 35-13 |
| Fri 11/19/21 | Class 5A Championship at UNI-Dome, vs. Southeast Polk | L 7-24 |