Centennial Football
| Date | Opponent | Results |
| Fri 8/27/21 | at Indianola | |
| Fri 9/3/21 | Ankeny | |
| Fri 9/10/21 | Waukee | |
| Fri 9/17/21 | at Cedar Falls | |
| Fri 9/24/21 | at Sioux City East | |
| Fri 10/1/21 | Urbandale | |
| Fri 10/8/21 | at Waukee Northwest | |
| Fri 10/15/21 | Southeast Polk | |
| Fri 10/22/21 | at Des Moines East | |
| Fri 10/29/21 | Class 4A Playoffs, First Round | |
| Fri 11/5/21 | Class 4A Quarterfinals, TBA | |
| Fri 11/12/21 | Class 4A Semifinals at UNI-Dome | |
| Fri 11/19/21 | Class 4A Championship at UNI-Dome |