Centennial Softball
| Date | Opponent | Results |
| Mon 5/24/21 | at Ottumwa (DH) | W 6-5, W 9-8 |
| Wed 5/26/21 | Newton | W 9-0 |
| Sat 5/29/21 | at Johnston, vs. Bettendorf | W 10-0 (6 inn.) |
| at Johnston | L 0-13 (4 inn.) | |
| Tue 6/1/21 | Fort Dodge (DH) | L 1-4, W 6-3 |
| Wed 6/2/21 | at Valley | L 0-10 (6 inn.) |
| Thu 6/3/21 | Roland-Story | W 6-0 |
| Mon 6/7/21 | at Marshalltown (DH) | W 4-0, W 9-1 |
| Tue 6/8/21 | at North Polk | W 2-1 |
| Wed 6/9/21 | Ankeny (DH) | W 6-5, L 6-13 |
| Mon 6/14/21 | at Ames (DH) | W 6-4 (10 inn.), W 5-4 |
| Tue 6/15/21 | Carlisle | W 5-4 (8 inn.) |
| Wed 6/16/21 | Mason City (DH) | W 13-1 (3 inn.), W 13-3 (5 inn.) |
| Thu 6/17/21 | Des Moines North (DH) | W 14-0 (3 inn.), W 21-0 (3 inn.) |
| Mon 6/21/21 | at Fort Dodge (DH) | L 0-1, L 2-3 |
| Tue 6/22/21 | Urbandale (DH) | L 4-8, W 2-0 (6 inn., rain) |
| Wed 6/23/21 | Marshalltown (DH) | W 11-1 (5 inn.), W 8-0 |
| Fri 6/25/21 | Prange Classic, vs. Estherville Lincoln Central | W 8-0 |
| vs. Urbandale | W 2-1 | |
| Mon 6/28/21 | at Ankeny (DH) | W 7-6, W 12-9 |
| Wed 6/30/21 | Ames (DH) | W 7-1, W 11-0 (5 inn.) |
| Fri 7/2/21 | at Dallas Center-Grimes, vs. Earlham | L 3-4 |
| at Dallas Center-Grimes | W 7-4 | |
| Tue 7/6/21 | at Mason City (DH) | W 15-0 (4 inn.), W 13-3 (6 inn.) |
| Mon 7/12/21 | vs. Ankeny, Class 5A Regional Semifinal | W 4-2 |
| Tue 7/13/21 | at Indianola, Class 5A Regional Final | W 3-2 |
| Tue 7/20/21 | at Fort Dodge, Class 5A Quarterfinal vs. Iowa City High | W 2-0 |
| Wed 7/21/21 | at Fort Dodge, Class 5A Semifinal vs. Pleasant Valley | W 8-1 |
| Fri 7/23/21 | at Fort Dodge, Class 5A Championship vs. Fort Dodge | L 0-2 |