Centennial Softball
| Date | Opponent | Results |
| Mon 5/23/22 | at Marshalltown (DH) | W 16-0 (3 inn.), W 14-0 |
| Fri 5/27/22 | at Johnston Invitational, vs. Johnston | L 0-10 (5 inn.) |
| vs. Bettendorf | W 5-4 | |
| Tue 5/31/22 | at Fort Dodge (DH) | L 2-3, L 2-4 |
| Wed 6/1/22 | Valley | W 11-1 (5 inn.) |
| Thu 6/2/22 | at Ankeny (DH) | W 8-5 (12 inn.), W 5-2 |
| Fri 6/3/22 | at Ballard Invitational, vs. Ballard | W 6-0 |
| vs. Central Springs | L 2-9 | |
| Mon 6/6/22 | at Waukee Northwest (DH) | L 1-2 (8 inn.), L 1-3 |
| Tue 6/7/22 | North Polk | W 5-2 |
| Mon 6/13/22 | Ames (DH) | W 7-6, W 11-3 |
| Tue 6/14/22 | at Carlisle | L 4-6 |
| Wed 6/15/22 | Mason City (DH) | W 12-0 (4 inn.), W 12-0 (3 inn.) |
| Thu 6/16/22 | Marshalltown (DH) | W 14-2 (4 inn.), W 11-0 (5 inn.) |
| Mon 6/20/22 | Fort Dodge (DH) | L 1-5, L 1-10 |
| Wed 6/22/22 | Waukee Northwest (DH) | L 4-5, L 2-13 (5 inn.) |
| Thu 6/23/22 | at Urbandale (DH) | W 10-2, W 9-3 |
| Sat 6/25/22 | Prange Classic at Centennial, vs. Davis County | W 9-0 |
| vs. Pleasantville | W 9-3 | |
| Tue 6/28/22 | at Roland-Story | W 11-0 (5 inn.) |
| Wed 6/29/22 | at Ames (DH) | L 2-4, W 8-1 |
| Thu 6/30/22 | Ankeny (DH) | W 5-1, W 4-3 |
| Fri 7/1/22 | at Dallas Center-Grimes Invitational, vs. North Polk | W 12-7 |
| vs. ADM | W 4-3 | |
| Sat 7/9/22 | Class 5A regional semifinal, vs. Waterloo West | W 4-3 |
| Tue 7/12/22 | Class 5A regional final, vs. Linn-Mar (Marion) | L 4-9 |