Centennial Softball
| Date | Opponent | Results |
| Mon 5/24/21 | at Ottumwa (DH) | W 6-5, W 9-8 |
| Wed 5/26/21 | Newton | W 9-0 |
| Sat 5/29/21 | at Johnston, vs. Bettendorf | W 10-0 (6 inn.) |
| at Johnston | L 0-13 (4 inn.) | |
| Tue 6/1/21 | Fort Dodge (DH) | L 1-4, W 6-3 |
| Wed 6/2/21 | at Valley | L 0-10 (6 inn.) |
| Thu 6/3/21 | Roland-Story | W 6-0 |
| Mon 6/7/21 | at Marshalltown (DH) | W 4-0, W 9-1 |
| Tue 6/8/21 | at North Polk | W 2-1 |
| Wed 6/9/21 | Ankeny (DH) | W 6-5, L 6-13 |
| Mon 6/14/21 | at Ames (DH) | |
| Tue 6/15/21 | Carlisle | |
| Wed 6/16/21 | Mason City (DH) | |
| Thu 6/17/21 | Des Moines North (DH) | |
| Mon 6/21/21 | at Fort Dodge (DH) | |
| Tue 6/22/21 | Urbandale (DH) | |
| Wed 6/23/21 | Marshalltown (DH) | |
| Fri 6/25/21 | Prange Classic, vs. ELC | |
| Urbandale | ||
| Sat 6/26/21 | Prange Classic, vs. Iowa City High | |
| Ballard (Huxley) | ||
| Mon 6/28/21 | at Ankeny (DH) | |
| Wed 6/30/21 | Ames (DH) | |
| Fri 7/2/21 | at Dallas Center-Grimes, vs. Earlham | |
| at Dallas Center-Grimes | ||
| Tue 7/6/21 | at Mason City (DH) | |
| Sat 7/10/21 | at TBA, Class 5A Regional Semifinal |