Ankeny Softball
| Date | Opponent | Results |
| Mon 5/24/21 | Urbandale (DH) | W 6-1, W 11-1 (5 inn.) |
| Thu 5/27/21 | Dallas Center-Grimes | W 14-4 (6 inn.) |
| Tue 6/1/21 | at Mason City (DH) | W 14-3 (5 inn.), W 12-0 (4 inn.) |
| Wed 6/2/21 | at Dowling Catholic | L 5-8 |
| Fri 6/4/21 | Carlisle | L 7-8 |
| Mon 6/7/21 | Fort Dodge (DH) | L 1-9, L 3-9 |
| Wed 6/9/21 | at Ankeny Centennial (DH) | L 5-6, W 13-6 |
| Fri 6/11/21 | at Creston, vs. Bondurant-Farrar | W 2-1 |
| vs. Atlantic | W 8-3 | |
| Mon 6/14/21 | Marshalltown (DH) | W 7-1, W 7-0 |
| Wed 6/16/21 | at Ames (DH) | L 5-7, W 11-4 |
| Thu 6/17/21 | at Southeast Polk (DH) | L 4-11, L 9-10 |
| Fri 6/18/21 | at Fort Dodge Invitational, vs. Central Springs | L 1-2 |
| vs. Sioux City Heelan | W 12-5 | |
| vs. Atlantic | L 4-8 | |
| vs. Sioux City East | W 12-0 (4 inn.) | |
| Mon 6/21/21 | Mason City (DH) | W 10-0 (5 inn.), L 5-6 |
| Wed 6/23/21 | at Fort Dodge (DH) | L 0-14 (4 inn.), L 5-15 (5 inn.) |
| Fri 6/25/21 | at Ankeny, Brent Prange Classic vs. Iowa City High | W 7-6 |
| Mon 6/28/21 | Ankeny Centennial (DH) | L 6-7, L 9-12 |
| Wed 6/30/21 | at Marshalltown (DH) | W 10-1, W 15-0 (3 inn.) |
| Fri 7/2/21 | at Ottumwa, vs. Fairfield | W 11-0 (5 inn.) |
| at Ottumwa | W 4-3 | |
| Sat 7/3/21 | North Polk | L 3-7 |
| Tue 7/6/21 | Ames (DH) | W 11-9, W 13-2 (5 inn.) |
| Mon 7/12/21 | at Ankeny Centennial, Class 5A Regional Semifinal | L 2-4 |