Ankeny Softball
| Date | Opponent | Results |
| Mon 5/23/22 | at Waukee Northwest (DH) | L 0-2, L 3-5 |
| Fri 5/27/22 | at Carlisle | W 7-2 |
| Tue 5/31/22 | Mason City (DH) | W 10-0 (5 inn.), W 7-4 |
| Thu 6/2/22 | Ankeny Centennial | L 5-8 (12 inn.), L 2-5 |
| Mon 6/6/22 | Ames (DH) | W 8-1, W 6-0 |
| Wed 6/8/22 | at Marshalltown (DH) | W 12-0 (6 inn.), W 22-2 (3 inn.) |
| Fri 6/10/22 | John Stevens Classic at Creston, vs. Atlantic | W 12-1 (6 inn.) |
| vs. Creston | W 15-0 (5 inn.) | |
| Sat 6/11/22 | vs. Mt. Ayr | W 4-3 |
| vs. Knoxville | W 5-3 | |
| Mon 6/13/22 | at Fort Dodge (DH) | W 2-1 (9 inn.), L 4-9 |
| Thu 6/16/22 | Waukee Northwest (DH) | L 1-10, W 6-4 |
| Fri 6/17/22 | at Fort Dodge Invitational, vs. Sioux City Heelan | W 10-3 |
| vs. Winterset | L 2-4 | |
| Sat 6/18/22 | vs. Ames | W 6-4 |
| vs. Ballard | W 7-4 | |
| Mon 6/20/22 | at Mason City (DH) | W 4-0, W 13-0 (4 inn.) |
| Wed 6/22/22 | at Ames (DH) | W 7-2, L 2-4 |
| Fri 6/24/22 | Brent Prange Classic at Ankeny, vs. Ballard | W 9-4 |
| vs. Davis County | W 9-0 | |
| Sat 6/25/22 | vs. Pleasantville | W 12-2 (5 inn.) |
| vs. Estherville-Lincoln Central | W 7-2 | |
| Mon 6/27/22 | Marshalltown (DH) | W 12-0 (3 inn.), W 15-3 (4 inn.) |
| Wed 6/29/22 | Fort Dodge (DH) | L 2-8, L 0-11 (5 inn.) |
| Thu 6/30/22 | at Ankeny Centennial (DH) | L 1-5, L 3-4 |
| Sat 7/2/22 | at North Polk | W 5-3 |
| Sat 7/9/22 | Class 5A regional semifinal, vs. C.R. Kennedy | W 13-2 (5 inn.) |
| Tue 7/12/22 | Class 5A regional final, at Southeast Polk | L 3-4 |