Centennial Girls’ Basketball
| Date | Opponent | Results |
| Tue 11/23/21 | at Des Moines North | W 44-30 |
| Fri 11/26/21 | at Urbandale | W 58-16 |
| Tue 11/30/21 | Southeast Polk | W 45-38 |
| Fri 12/3/21 | Fort Dodge | W 72-40 |
| Tue 12/7/21 | at Des Moines Lincoln | |
| Fri 12/10/21 | at Mason City | |
| Tue 12/14/21 | at Johnston | |
| Tue 12/21/21 | at Waukee Northwest | |
| Tue 1/4/22 | Waukee Northwest | |
| Fri 1/7/22 | Ames | |
| Tue 1/11/22 | Ankeny | |
| Fri 1/14/22 | at Fort Dodge | |
| Sat 1/15/22 | Marshalltown | |
| Tue 1/18/22 | Des Moines Hoover | |
| Fri 1/21/22 | Mason City | |
| Tue 1/25/22 | at Des Moines East | |
| Fri 1/28/22 | at Marshalltown | |
| Tue 2/1/22 | Waukee | |
| Fri 2/4/22 | at Ames | |
| Tue 2/8/22 | Dowling Catholic | |
| Fri 2/11/22 | at Ankeny | |
| Sat 2/19/22 | Class 5A regional semifinal, TBA | |
| Tue 2/22/22 | Class 5A regional final, TBA | |
| Tue-Sat 3/1-5/22 | at Wells Fargo Arena, Class 5A state tournament |