Centennial Girls’ Basketball
| Date | Opponent | Results |
| Tue 11/23/21 | at Des Moines North | W 44-30 |
| Fri 11/26/21 | at Urbandale | W 58-16 |
| Tue 11/30/21 | Southeast Polk | W 45-38 |
| Fri 12/3/21 | Fort Dodge | W 72-40 |
| Tue 12/7/21 | at Des Moines Lincoln | W 45-12 |
| Tue 12/14/21 | at Johnston | L 39-48 |
| Thu 12/16/21 | at Mason City | W 39-31 |
| Tue 12/21/21 | at Waukee Northwest | L 39-45 |
| Tue 1/4/22 | Waukee Northwest | W 33-25 |
| Fri 1/7/22 | Ames | W 71-10 |
| Tue 1/11/22 | Ankeny | W 57-37 |
| Tue 1/18/22 | Des Moines Hoover | W 75-17 |
| Thu 1/20/22 | at Fort Dodge | W 57-51 |
| Fri 1/21/22 | Mason City | W 67-17 |
| Tue 1/25/22 | at Des Moines East | W 82-8 |
| Fri 1/28/22 | at Marshalltown | W 66-23 |
| Tue 2/1/22 | Waukee | W 42-32 |
| Thu 2/3/22 | Marshalltown | W 59-6 |
| Fri 2/4/22 | at Ames | W 53-15 |
| Tue 2/8/22 | Dowling Catholic | W 41-31 |
| Fri 2/11/22 | at Ankeny | L 45-49 |
| Sat 2/19/22 | Class 5A regional semifinal, vs. Marshalltown | W 73-22 |
| Wed 2/23/22 | Class 5A regional final, vs. Sioux City East | W 46-41 |
| Mon 2/28/22 | at Wells Fargo Arena, Class 5A quarterfinal vs. Waterloo West | L 59-67 |