Centennial Football
| Date | Opponent | Results |
| Fri 8/30/25 | at Northview, vs. Ankeny (Junior Football Night) | |
| Fri 9/6/25 | Ames (Jaguar Spirit Night) | |
| Fri 9/13/25 | at Cedar Falls | |
| Fri 9/20/25 | Southeast Polk (Homecoming) | |
| Fri 9/27/25 | at Des Moines East | |
| Fri 10/4/25 | at Valley Stadium, vs. Dowling Catholic | |
| Fri 10/11/25 | Des Moines Roosevelt | |
| Fri 10/18/25 | at Waukee Northwest | |
| Fri 10/25/25 | Urbandale (Senior Night) | |
| Fri 11/1/25 | vs. Iowa City High, Class 5A First Round | |
| Fri 11/8/25 | vs. Dowling Catholic, Class 5A quarterfinal at Mediacom Stadium |