Centennial Softball
| Date | Opponent | Results |
| Tue 5/27/25 | at Norwalk | |
| Wed 5/28/25 | at Waukee | L 3-4 |
| Thu 5/29/25 | at Johnston (DH) | |
| Fri 5/30/25 | Des Moines Lincoln (DH) | |
| Mon 6/2/25 | at Ankeny | |
| Wed 6/4/25 | Southeast Polk (DH) | |
| Thu 6/5/25 | at Waukee Northwest (DH) | |
| Fri 6/6/25 | Creston | |
| Ames | ||
| Mon 6/9/25 | Dowling Catholic (DH) | |
| Thu 6/12/25 | at Valley (DH) | |
| Fri 6/13/25 | Cedar Falls (DH) | |
| Sat 6/14/25 | at Linn-Mar (Marion) (DH) | |
| Mon 6/16/25 | Urbandale | |
| Wed 6/18/25 | Waukee (DH) | |
| Thu 6/19/25 | Johnston | |
| Fri-Sat 6/20-21/25 | at Fort Dodge Invitational | |
| Mon 6/23/25 | at Southeast Polk | |
| Wed 6/25/25 | Ankeny (DH) | |
| Thu 6/26/25 | Waukee Northwest | |
| Tue 7/1/25 | Fort Dodge (Senior Night) | |
| Wed 7/2/25 | at Dowling Catholic | |
| Thu 7/3/25 | at Dallas Center-Grimes Invitational | |
| Sat 7/5/25 | Valley | |
| Mon 7/7/25 | at Urbandale (DH) | |
| Sat 7/12/25 | at TBA, Class 5A regional semifinal | |
| Tue 7/15/25 | at TBA, Class 5A regional final | |
| Mon-Thu 7/21-24/25 | at Fort Dodge, Class 5A state tournament |